Reactome | SCNN channels transport extracellular Na+ to cytosol

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SCNN channels transport extracellular Na+ to cytosol Show undefined attributes

authored	[InstanceEdit:2672349] Jassal, Bijay, 2012-11-27
catalystActivity	[CatalystActivity:2672338] ligand-gated sodium channel activity of SCNN channels [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2672349] Jassal, Bijay, 2012-11-27
crossReference	[DatabaseIdentifier:12667893] RHEA:34963
dbId	2672334
displayName	SCNN channels transport extracellular Na+ to cytosol
edited	[InstanceEdit:2672349] Jassal, Bijay, 2012-11-27
eventOf	[Pathway:R-HSA-9730628] Sensory perception of salty taste - Homo sapiens [Pathway:R-HSA-2672351] Stimuli-sensing channels - Homo sapiens
followingEvent	[Reaction:R-HSA-9717392] CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3189822] Amiloride-sensitive Na channels [LiteratureReference:9730629] Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SCNN channels transport extracellular Na+ to cytosol Extracellular Na+ is transported to cytosol by SCNN channel
orthologousEvent	[Reaction:R-CEL-2672334] SCNN channels transport extracellular Na+ to cytosol - Caenorhabditis elegans [Reaction:R-DME-2672334] SCNN channels transport extracellular Na+ to cytosol - Drosophila melanogaster [Reaction:R-GGA-2672334] SCNN channels transport extracellular Na+ to cytosol - Gallus gallus [Reaction:R-XTR-2672334] SCNN channels transport extracellular Na+ to cytosol - Xenopus tropicalis [Reaction:R-SSC-2672334] SCNN channels transport extracellular Na+ to cytosol - Sus scrofa [Reaction:R-BTA-2672334] SCNN channels transport extracellular Na+ to cytosol - Bos taurus [Reaction:R-CFA-2672334] SCNN channels transport extracellular Na+ to cytosol - Canis familiaris [Reaction:R-RNO-2672334] SCNN channels transport extracellular Na+ to cytosol - Rattus norvegicus [Reaction:R-MMU-2672334] SCNN channels transport extracellular Na+ to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-2672371] Negative regulation by 'amiloride [extracellular region]'
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3002750] He, Lei, 2013-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2672334
summation	[Summation:2672389] Amiloride-sensitive sodium channels (SCNNs, aka ENaCs, epith...
updateTrackers	[UpdateTracker:9776237] Update Tracker - [Reaction:2672334] SCNN channels transport extracellular Na+ to cytosol - v77:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9776237] Update Tracker - [Reaction:2672334] SCNN channels transport extracellular Na+ to cytosol - v77:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9730628] Sensory perception of salty taste [Pathway:R-HSA-2672351] Stimuli-sensing channels
(precedingEvent)	[Reaction:R-HSA-9717392] CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region