Reactome | The canonical retinoid cycle in rods (twilight vision)

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The canonical retinoid cycle in rods (twilight vision) Show undefined attributes

authored	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
created	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
dbId	2453902
displayName	The canonical retinoid cycle in rods (twilight vision)
doi	10.3180/REACT_160156.1
edited	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
eventOf	[Pathway:R-HSA-2187338] Visual phototransduction - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:26144] retinoid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2453876] TTR:RBP:atROL binds to STRA6 receptor - Homo sapiens [Reaction:R-HSA-2453863] STRA6 transports atROL from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-74843] atROL binds RBP1 to form RBP1:atROL - Homo sapiens [Reaction:R-HSA-2453855] LRAT esterifies RBP1:atROL and FACYLs to atREs - Homo sapiens [Reaction:R-HSA-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Homo sapiens [Reaction:R-HSA-2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL - Homo sapiens [Reaction:R-HSA-74872] RDH10,11 oxidise 11cROL to 11cRAL - Homo sapiens [Reaction:R-HSA-2454081] RDH5 oxidises 11cROL to 11cRAL - Homo sapiens [Reaction:R-HSA-8960973] RLBP1:11cRAL dissociates - Homo sapiens [BlackBoxEvent:R-HSA-2454113] RBP3 transports 11cRAL to rod photoreceptor outer segment - Homo sapiens [Reaction:R-HSA-2454118] 11cRAL binds to opsin to form 11c-retinyl:RHO - Homo sapiens [Reaction:R-HSA-74101] Photons induce isomerization of 11c-retinyl to at-retinyl - Homo sapiens [Reaction:R-HSA-1467466] ABCA4 mediates atRAL transport - Homo sapiens [Reaction:R-HSA-2466749] ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol - Homo sapiens [Reaction:R-HSA-2466718] NRPE dissociates to atRAL and PE - Homo sapiens [Reaction:R-HSA-2464810] atRAL(membrane) diffuses to atRAL(cytosol) - Homo sapiens [Reaction:R-HSA-2464822] RDH12 reduces atRAL to atROL - Homo sapiens [Reaction:R-HSA-2464803] RDH8 reduces atRAL to atROL - Homo sapiens [BlackBoxEvent:R-HSA-2464809] RBP3 regulates the transport of atROL from ROS to RPE - Homo sapiens [Reaction:R-HSA-6786239] CYP4V2 omega-hydroxylates DHA to HDoHE - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-06-17
literatureReference	[LiteratureReference:2464789] Metabolism of carotenoids and retinoids related to vision [LiteratureReference:2464788] Overview of retinoid metabolism and function [LiteratureReference:2464772] The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision [LiteratureReference:2425425] Vitamin A metabolism: an update
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	The canonical retinoid cycle in rods (twilight vision)
orthologousEvent	[Pathway:R-MMU-2453902] The canonical retinoid cycle in rods (twilight vision) - Mus musculus [Pathway:R-RNO-2453902] The canonical retinoid cycle in rods (twilight vision) - Rattus norvegicus [Pathway:R-CFA-2453902] The canonical retinoid cycle in rods (twilight vision) - Canis familiaris [Pathway:R-BTA-2453902] The canonical retinoid cycle in rods (twilight vision) - Bos taurus [Pathway:R-SSC-2453902] The canonical retinoid cycle in rods (twilight vision) - Sus scrofa [Pathway:R-DRE-2453902] The canonical retinoid cycle in rods (twilight vision) - Danio rerio [Pathway:R-XTR-2453902] The canonical retinoid cycle in rods (twilight vision) - Xenopus tropicalis [Pathway:R-GGA-2453902] The canonical retinoid cycle in rods (twilight vision) - Gallus gallus [Pathway:R-DME-2453902] The canonical retinoid cycle in rods (twilight vision) - Drosophila melanogaster [Pathway:R-CEL-2453902] The canonical retinoid cycle in rods (twilight vision) - Caenorhabditis elegans [Pathway:R-DDI-2453902] The canonical retinoid cycle in rods (twilight vision) - Dictyostelium discoideum [Pathway:R-PFA-2453902] The canonical retinoid cycle in rods (twilight vision) - Plasmodium falciparum
precedingEvent	[Pathway:R-HSA-975634] Retinoid metabolism and transport - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-03-12
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9919312] Matthews, Lisa, 2024-08-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2453902
summation	[Summation:2464824] The retinoid cycle (also referred to as the visual cycle) is...
updateTrackers	[UpdateTracker:9781560] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9786728] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v48:[addHasEvent, updateContainedRLE] [UpdateTracker:9919352] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v90:[addHasEvent] [UpdateTracker:9782530] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v59:[updateContainedRLE] [UpdateTracker:9783891] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v55:[addHasEvent] [UpdateTracker:9777053] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v73:[updateContainedRLE] [UpdateTracker:9787508] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v45:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-2187338] Visual phototransduction

(updatedInstance)

[UpdateTracker:9781560] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786728] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v48:[addHasEvent, updateContainedRLE]
[UpdateTracker:9919352] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v90:[addHasEvent]
[UpdateTracker:9782530] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v59:[updateContainedRLE]
[UpdateTracker:9783891] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v55:[addHasEvent]
[UpdateTracker:9777053] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v73:[updateContainedRLE]
[UpdateTracker:9787508] Update Tracker - [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) - v45:[updateContainedRLE]

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