Reactome | RPE65 isomero-hydrolyses atREs to 11cROL

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RPE65 isomero-hydrolyses atREs to 11cROL Show undefined attributes

authored	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
catalystActivity	[CatalystActivity:2453844] all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity of RPE65 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13977] lipid droplet [Compartment:876] plasma membrane
created	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
dbId	2453833
displayName	RPE65 isomero-hydrolyses atREs to 11cROL
edited	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
eventOf	[Pathway:R-HSA-2453902] The canonical retinoid cycle in rods (twilight vision) - Homo sapiens
followingEvent	[Reaction:R-HSA-2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL - Homo sapiens
input	[SimpleEntity:R-ALL-9982476] atRE [lipid droplet] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2453806] Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65 [LiteratureReference:2454082] The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RPE65 isomero-hydrolyses atREs to 11cROL Retinoid isomerohydrolase isomero-hydrolyses retinyl esters to 11-cis-retinol
orthologousEvent	[Reaction:R-CEL-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Caenorhabditis elegans [Reaction:R-DME-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Drosophila melanogaster [Reaction:R-GGA-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Gallus gallus [Reaction:R-XTR-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Xenopus tropicalis [Reaction:R-DRE-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Danio rerio [Reaction:R-SSC-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Sus scrofa [Reaction:R-BTA-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Bos taurus [Reaction:R-CFA-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Canis familiaris [Reaction:R-RNO-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Rattus norvegicus [Reaction:R-MMU-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Mus musculus
output	[SimpleEntity:R-ALL-30927] 11cROL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-9982478] RCOO- [lipid droplet]
precedingEvent	[Reaction:R-HSA-2453855] LRAT esterifies RBP1:atROL and FACYLs to atREs - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:R-HSA-2454123] Positive regulation by 'MYO7A [cytosol]'
regulationReference	[RegulationReference:9642038] Positive regulation by 'MYO7A [cytosol]' The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
releaseDate	2013-03-12
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9982754] D'Eustachio, Peter, 2026-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2453833
summation	[Summation:2453897] All-trans-retinol esters (atREs) serve as substrates for ret...
updateTrackers	[UpdateTracker:9984653] Update Tracker - [Reaction:2453833] RPE65 isomero-hydrolyses atREs to 11cROL - v96:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984653] Update Tracker - [Reaction:2453833] RPE65 isomero-hydrolyses atREs to 11cROL - v96:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-2453902] The canonical retinoid cycle in rods (twilight vision)
(precedingEvent)	[Reaction:R-HSA-2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL