Reactome | The canonical retinoid cycle in rods (twilight vision)

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The canonical retinoid cycle in rods (twilight vision) Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10555837
displayName	The canonical retinoid cycle in rods (twilight vision)
eventOf	[Pathway:R-SSC-2187338] Visual phototransduction - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:26144] retinoid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-2453876] TTR:RBP:atROL binds to STRA6 receptor - Sus scrofa [Reaction:R-SSC-2453863] STRA6 transports atROL from extracellular region to cytosol - Sus scrofa [Reaction:R-SSC-74843] atROL binds RBP1 to form RBP1:atROL - Sus scrofa [Reaction:R-SSC-2453855] LRAT esterifies RBP1:atROL and FACYLs to atREs - Sus scrofa [Reaction:R-SSC-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Sus scrofa [Reaction:R-SSC-2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL - Sus scrofa [Reaction:R-SSC-74872] RDH10,11 oxidise 11cROL to 11cRAL - Sus scrofa [Reaction:R-SSC-2454081] RDH5 oxidises 11cROL to 11cRAL - Sus scrofa [Reaction:R-SSC-8960973] RLBP1:11cRAL dissociates - Sus scrofa [BlackBoxEvent:R-SSC-2454113] RBP3 transports 11cRAL to rod photoreceptor outer segment - Sus scrofa [Reaction:R-SSC-2454118] 11cRAL binds to opsin to form 11c-retinyl:RHO - Sus scrofa [Reaction:R-SSC-74101] Photons induce isomerization of 11c-retinyl to at-retinyl - Sus scrofa [Reaction:R-SSC-1467466] ABCA4 mediates atRAL transport - Sus scrofa [Reaction:R-SSC-2464822] RDH12 reduces atRAL to atROL - Sus scrofa [BlackBoxEvent:R-SSC-2464809] RBP3 regulates the transport of atROL from ROS to RPE - Sus scrofa [Reaction:R-SSC-6786239] CYP4V2 omega-hydroxylates DHA to HDoHE - Sus scrofa
inferredFrom	[Pathway:R-HSA-2453902] The canonical retinoid cycle in rods (twilight vision) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	The canonical retinoid cycle in rods (twilight vision)
precedingEvent	[Pathway:R-SSC-975634] Retinoid metabolism and transport - Sus scrofa
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2453902
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-2453902] The canonical retinoid cycle in rods (twilight vision)
(hasEvent)	[Pathway:R-SSC-2187338] Visual phototransduction