Reactome | ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol

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ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol Show undefined attributes

authored	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
catalystActivity	[CatalystActivity:1467465] retinol transmembrane transporter activity of ABCA4 [photoreceptor disc membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:2514888] photoreceptor disc membrane [Compartment:74000] photoreceptor outer segment membrane
created	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
dbId	2466749
diseaseReaction	[FailedReaction:R-HSA-2466802] Defective ABCA4 does not transport NRPE from disc membranes - Homo sapiens
displayName	ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol
edited	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
eventOf	[Pathway:R-HSA-2453902] The canonical retinoid cycle in rods (twilight vision) - Homo sapiens
followingEvent	[Reaction:R-HSA-2466718] NRPE dissociates to atRAL and PE - Homo sapiens
inferredFrom	[Reaction:R-BTA-2466767] NRPE is a substrate for Abca4 - Bos taurus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-2466859] NRPE [photoreceptor outer segment membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2466779] The human photoreceptor rim protein gene (ABCR): genomic structure and primer set information for mutation analysis [LiteratureReference:2466714] N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR)
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol NRPE is a substrate for ABCA4
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-2466716] NRPE [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-2466846] atRAL can spontaneously react with PE to form NRPE - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2466749
summation	[Summation:2466806] Bovine studies (Beharry et al. 2004) have indicated NRPE to ...
updateTrackers	[UpdateTracker:9786776] Update Tracker - [Reaction:2466749] ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol - v48:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786776] Update Tracker - [Reaction:2466749] ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol - v48:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-2466802] Defective ABCA4 does not transport NRPE from disc membranes
(hasEvent)	[Pathway:R-HSA-2453902] The canonical retinoid cycle in rods (twilight vision)
(precedingEvent)	[Reaction:R-HSA-2466718] NRPE dissociates to atRAL and PE
(inferredTo)	[Reaction:R-BTA-2466767] NRPE is a substrate for Abca4

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