Reactome | PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:2243940] protein serine/threonine kinase activity of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
created	[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575
dbId	2243941
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:1500575] ovarian cancer
displayName	PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
hasComponent	[Complex:R-HSA-2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] [Complex:R-HSA-2219520] PDPK1:PIP2 [plasma membrane]
inDisease	true
isChimeric	false
maxDepth	3
name	PDPK1:p-S473-AKT1 E17K mutant:PIP2
producedByEvent	[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2243941

(output)	[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
(input)	[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant
(diseaseEntity)	[EntityFunctionalStatus:3080614] gain_of_function of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
(physicalEntity)	[CatalystActivity:2243940] protein serine/threonine kinase activity of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]

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