Reactome | JAK2 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

JAK2 [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-8987151] JAK2, JAK3 [cytosol] - Homo sapiens [CandidateSet:R-HSA-5672734] RAF activating kinases [plasma membrane] - Homo sapiens
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-912316] pY593,Y628-IL3RB:JAK2 [plasma membrane] - Homo sapiens [Complex:R-HSA-879945] IL3RB:JAK2 [plasma membrane] - Homo sapiens [Complex:R-HSA-9670384] KIT mutant dimers:SFKs:JAK2 [plasma membrane] - Homo sapiens [Complex:R-HSA-9670384] KIT mutant dimers:SFKs:JAK2 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1302698] PRLR associates with JAK2 - Homo sapiens [Reaction:R-HSA-1433451] JAK2 binds to p-KIT - Homo sapiens [Reaction:R-HSA-1433451] JAK2 binds to p-KIT - Homo sapiens [Reaction:R-HSA-9670413] JAK2 binds to p-KIT mutants - Homo sapiens [Reaction:R-HSA-9670413] JAK2 binds to p-KIT mutants - Homo sapiens [Reaction:R-HSA-8950063] IL12RB2 binds JAK2 - Homo sapiens [Reaction:R-HSA-8950737] IL23R binds JAK2 - Homo sapiens [Reaction:R-HSA-879937] The common beta chain IL3RB binds JAK2 - Homo sapiens [Reaction:R-HSA-6785898] IL4R binds JAK2 - Homo sapiens [Reaction:R-HSA-982792] Growth hormone receptor binds JAK2 - Homo sapiens [BlackBoxEvent:R-HSA-9676071] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK - Homo sapiens
created	[InstanceEdit:210618] Williams, MG, 2008-01-15 15:30:58
dbId	210620
displayName	JAK2 [cytosol]
endCoordinate	1132
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-210620] JAK2 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-1168889] Jak2 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-210620] JAK2 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-210620] JAK2 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-210620] JAK2 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-210620] JAK2 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-210620] JAK2 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-210620] JAK2 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-210620] JAK2 [cytosol] - Drosophila melanogaster
maxDepth	1
memberOf	[CandidateSet:R-HSA-1067656] JAK1, JAK2, (TYK2) [cytosol] - Homo sapiens
modified	[InstanceEdit:8949827] Jupe, Steve, 2016-11-29
name	JAK2 Tyrosine-protein kinase JAK2
referenceEntity	[ReferenceGeneProduct:uniprot:O60674] UniProt:O60674 JAK2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-210620
startCoordinate	1
updateTrackers	[UpdateTracker:9876052] Update Tracker - [EntityWithAccessionedSequence:210620] JAK2 [cytosol] - v44:[modifyEndCoordinate] [UpdateTracker:9895842] Update Tracker - [EntityWithAccessionedSequence:210620] JAK2 [cytosol] - v60:[addName]

Referrals

(hasComponent)	[Complex:R-HSA-912316] pY593,Y628-IL3RB:JAK2 [plasma membrane] [Complex:R-HSA-879945] IL3RB:JAK2 [plasma membrane] [Complex:R-HSA-873808] IFNGR2:JAK2 [plasma membrane] [Complex:R-HSA-6786120] p-Y-IL4R:JAK2 [plasma membrane] [Complex:R-HSA-6785800] IL4R:JAK2 [plasma membrane] [Complex:R-HSA-2586523] LEPR:JAK2 [plasma membrane] [Complex:R-HSA-1168397] Activated Growth Hormone Receptor:JAK2 [plasma membrane] [Complex:R-HSA-1977936] Activated PRLR:JAK2 [plasma membrane] [Complex:R-HSA-982774] Growth Hormone Receptor:JAK2 [plasma membrane] [Complex:R-HSA-1302663] PRLR:JAK2 [plasma membrane] [Complex:R-HSA-1370506] p(S349)-PRLR:JAK2 [plasma membrane] [Complex:R-HSA-9006298] EPOR:JAK2:LYN:IRS2 [plasma membrane] [Complex:R-HSA-914173] p-S585-IL3RB:JAK2 [plasma membrane] [Complex:R-HSA-914033] p(Y593)-Bc:JAK2 [plasma membrane] [Complex:R-HSA-1433493] JAK2:SFKS:p-KIT complex [plasma membrane] [Complex:R-HSA-9670384] KIT mutant dimers:SFKs:JAK2 [plasma membrane] [Complex:R-HSA-1169223] Tyrosine phosphorylated Growth Hormone Receptor:JAK2 [plasma membrane] [Complex:R-HSA-8950039] IL12RB2:JAK2 [plasma membrane] [Complex:R-HSA-8950151] IL23R:JAK2 [plasma membrane]
(input)	[Reaction:R-HSA-8950737] IL23R binds JAK2 [Reaction:R-HSA-879937] The common beta chain IL3RB binds JAK2 [Reaction:R-HSA-6785898] IL4R binds JAK2 [Reaction:R-HSA-982792] Growth hormone receptor binds JAK2 [Reaction:R-HSA-1302698] PRLR associates with JAK2 [Reaction:R-HSA-1433451] JAK2 binds to p-KIT [Reaction:R-HSA-9670413] JAK2 binds to p-KIT mutants [BlackBoxEvent:R-HSA-9676071] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK [Reaction:R-HSA-8950063] IL12RB2 binds JAK2
(hasMember)	[CandidateSet:R-HSA-1067656] JAK1, JAK2, (TYK2) [cytosol]
(activeUnit)	[CatalystActivity:873920] protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] [CatalystActivity:2586550] protein tyrosine kinase activity of LEP:LEPR:JAK2 [plasma membrane] [CatalystActivity:9006324] protein tyrosine kinase activity of EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane] [CatalystActivity:914083] non-membrane spanning protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] [CatalystActivity:2447206] protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane] [CatalystActivity:9670409] protein tyrosine kinase activity of KIT mutant dimers:SFKs:JAK2 [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-5672734] RAF activating kinases [plasma membrane] [CandidateSet:R-HSA-8987151] JAK2, JAK3 [cytosol]
(updatedInstance)	[UpdateTracker:9876052] Update Tracker - [EntityWithAccessionedSequence:210620] JAK2 [cytosol] - v44:[modifyEndCoordinate] [UpdateTracker:9895842] Update Tracker - [EntityWithAccessionedSequence:210620] JAK2 [cytosol] - v60:[addName]

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