Reactome | JAK2 binds to p-KIT mutants

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JAK2 binds to p-KIT mutants Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9670415] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670413
disease	[Disease:1500689] cancer
displayName	JAK2 binds to p-KIT mutants
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9670386] gain_of_function of KIT mutant dimers:SFKs [plasma membrane]
eventOf	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9670418] Phosphorylation of JAK2 downstream of KIT mutants - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-210620] JAK2 [cytosol] [Complex:R-HSA-9670368] KIT mutant dimers:SFKs [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1433426] STAT protein recruitment and activation in c-Kit deletion mutants [LiteratureReference:9670498] Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells [LiteratureReference:9669059] Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412 [LiteratureReference:9669122] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors [LiteratureReference:9670495] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors [LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 binds to p-KIT mutants
normalReaction	[Reaction:R-HSA-1433451] JAK2 binds to p-KIT
output	[Complex:R-HSA-9670384] KIT mutant dimers:SFKs:JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9670414] KIT mutants bind SFKs - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670413
summation	[Summation:9670518] Activation of STAT signaling has been observed downstream of...

Referrals

(hasEvent)	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
(precedingEvent)	[Reaction:R-HSA-9670418] Phosphorylation of JAK2 downstream of KIT mutants