Reactome | CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK

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CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK Show undefined attributes

authored	[InstanceEdit:9675009] May, Bruce, 2020-01-29
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9676073] May, Bruce, 2020-02-07
dbId	9676071
displayName	CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
edited	[InstanceEdit:9675009] May, Bruce, 2020-01-29
eventOf	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9674808] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) - Homo sapiens [Reaction:R-HSA-9674562] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9676072] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2 - Mus musculus
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9674572] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167708] HCK [cytosol] [EntityWithAccessionedSequence:R-HSA-210620] JAK2 [cytosol] [EntityWithAccessionedSequence:R-HSA-58268] SYK [cytosol] [EntityWithAccessionedSequence:R-HSA-877348] TYK2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9677131] Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA [LiteratureReference:9674947] The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line [LiteratureReference:9674969] Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9676067] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9674558] p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9676071
summation	[Summation:9677141] The kinases JAK2 (Shimoda et al. 1997, Marino and Roguin 200...

Referrals

(hasEvent)	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF)
(precedingEvent)	[BlackBoxEvent:R-HSA-9674808] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) [Reaction:R-HSA-9674562] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
(inferredTo)	[BlackBoxEvent:R-MMU-9676072] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2

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