Reactome | Some HSPGs are secreted to the plasma membrane

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Some HSPGs are secreted to the plasma membrane Show undefined attributes

authored	[InstanceEdit:2024092] Jassal, B, 2011-12-14
category	omitted
compartment	[Compartment:17963] Golgi lumen [Compartment:876] plasma membrane
created	[InstanceEdit:2024092] Jassal, B, 2011-12-14
dbId	2024108
displayName	Some HSPGs are secreted to the plasma membrane
edited	[InstanceEdit:2024092] Jassal, B, 2011-12-14
eventOf	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans - Homo sapiens [Reaction:R-HSA-9792569] proHPSE binds SDC1 - Homo sapiens [BlackBoxEvent:R-HSA-2024084] HS-GAGs translocate to the lysosome for degradation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160306] Golgi to plasma membrane protein transport
input	[DefinedSet:R-HSA-2076619] HSPGs [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1666986] Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Some HSPGs are secreted to the plasma membrane
orthologousEvent	[BlackBoxEvent:R-BTA-2024108] Some HSPGs are secreted to the plasma membrane - Bos taurus [BlackBoxEvent:R-CEL-2024108] Some HSPGs are secreted to the plasma membrane - Caenorhabditis elegans [BlackBoxEvent:R-DME-2024108] Some HSPGs are secreted to the plasma membrane - Drosophila melanogaster [BlackBoxEvent:R-GGA-2024108] Some HSPGs are secreted to the plasma membrane - Gallus gallus [BlackBoxEvent:R-XTR-2024108] Some HSPGs are secreted to the plasma membrane - Xenopus tropicalis [BlackBoxEvent:R-DRE-2024108] Some HSPGs are secreted to the plasma membrane - Danio rerio [BlackBoxEvent:R-SSC-2024108] Some HSPGs are secreted to the plasma membrane - Sus scrofa [BlackBoxEvent:R-CFA-2024108] Some HSPGs are secreted to the plasma membrane - Canis familiaris [BlackBoxEvent:R-RNO-2024108] Some HSPGs are secreted to the plasma membrane - Rattus norvegicus [BlackBoxEvent:R-MMU-2024108] Some HSPGs are secreted to the plasma membrane - Mus musculus
output	[DefinedSet:R-HSA-2076618] HSPGs [plasma membrane]
precedingEvent	[Reaction:R-HSA-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Homo sapiens [Reaction:R-HSA-2024100] GLCE epimerises GlcA to IdoA - Homo sapiens [Reaction:R-HSA-2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises - Homo sapiens [Reaction:R-HSA-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate - Homo sapiens [Reaction:R-HSA-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Homo sapiens [Reaction:R-HSA-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Homo sapiens [Reaction:R-HSA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2024108
summation	[Summation:2024087] Depending on the nature of the core protein HS-GAGs are atta...

Referrals

(hasEvent)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-HSA-1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans [Reaction:R-HSA-9792569] proHPSE binds SDC1 [BlackBoxEvent:R-HSA-2024084] HS-GAGs translocate to the lysosome for degradation

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