Reactome | HS6STs sulfate GlcN at C6 in heparan sulfate/heparin

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HS6STs sulfate GlcN at C6 in heparan sulfate/heparin Show undefined attributes

authored	[InstanceEdit:2076352] Jassal, B, 2012-01-27
catalystActivity	[CatalystActivity:2076304] heparan sulfate 6-sulfotransferase activity of HS6STs [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2076352] Jassal, B, 2012-01-27
crossReference	[DatabaseIdentifier:9941342] RHEA:56605
dbId	2076419
displayName	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
edited	[InstanceEdit:2076352] Jassal, B, 2012-01-27
eventOf	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
input	[DefinedSet:R-HSA-2076461] HS(5)-PGs [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2076589] Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells [LiteratureReference:2076435] Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties [LiteratureReference:2076385] The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine [LiteratureReference:9941357] Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism [LiteratureReference:9941168] A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
orthologousEvent	[Reaction:R-BTA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Bos taurus [Reaction:R-CEL-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Caenorhabditis elegans [Reaction:R-DME-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Drosophila melanogaster [Reaction:R-GGA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Gallus gallus [Reaction:R-XTR-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Xenopus tropicalis [Reaction:R-DRE-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Danio rerio [Reaction:R-SSC-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Sus scrofa [Reaction:R-CFA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Canis familiaris [Reaction:R-RNO-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Rattus norvegicus [Reaction:R-MMU-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-HSA-2076357] HS/HPIN-PGs [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises - Homo sapiens [Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2076419
summation	[Summation:2076373] Heparan-sulfate 6-O-sulfotransferases 1 and 2 (HS3ST1-2) (H...
updateTrackers	[UpdateTracker:9953709] Update Tracker - [Reaction:2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - v93:[modifyText, removeLiteratureReference, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9953709] Update Tracker - [Reaction:2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - v93:[modifyText, removeLiteratureReference, removeOutput]
(hasEvent)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis
(precedingEvent)	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane

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