Reactome | HS-GAGs translocate to the lysosome for degradation

Schema > BlackBoxEvent > Entries

HS-GAGs translocate to the lysosome for degradation Show undefined attributes

authored	[InstanceEdit:2024092] Jassal, B, 2011-12-14
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:161320] lysosomal lumen
created	[InstanceEdit:2024092] Jassal, B, 2011-12-14
dbId	2024084
displayName	HS-GAGs translocate to the lysosome for degradation
edited	[InstanceEdit:2024092] Jassal, B, 2011-12-14
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6597] endocytosis
input	[DefinedSet:R-HSA-2076639] HS/HPIN-PGs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2046141] Lysosomal metabolism of glycoproteins [LiteratureReference:9774309] Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HS-GAGs translocate to the lysosome for degradation
orthologousEvent	[BlackBoxEvent:R-BTA-2024084] HS-GAGs translocate to the lysosome for degradation - Bos taurus [BlackBoxEvent:R-CEL-2024084] HS-GAGs translocate to the lysosome for degradation - Caenorhabditis elegans [BlackBoxEvent:R-DME-2024084] HS-GAGs translocate to the lysosome for degradation - Drosophila melanogaster [BlackBoxEvent:R-GGA-2024084] HS-GAGs translocate to the lysosome for degradation - Gallus gallus [BlackBoxEvent:R-XTR-2024084] HS-GAGs translocate to the lysosome for degradation - Xenopus tropicalis [BlackBoxEvent:R-DRE-2024084] HS-GAGs translocate to the lysosome for degradation - Danio rerio [BlackBoxEvent:R-SSC-2024084] HS-GAGs translocate to the lysosome for degradation - Sus scrofa [BlackBoxEvent:R-CFA-2024084] HS-GAGs translocate to the lysosome for degradation - Canis familiaris [BlackBoxEvent:R-RNO-2024084] HS-GAGs translocate to the lysosome for degradation - Rattus norvegicus [BlackBoxEvent:R-MMU-2024084] HS-GAGs translocate to the lysosome for degradation - Mus musculus
output	[DefinedSet:R-HSA-2090050] HS/HPIN-PGs [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9941254] Negative regulation by 'HPSE2:HS/HPIN-PGs [plasma membrane]'
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9774317] Hill, David P, 2022-05-20 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
revised	[InstanceEdit:9774306] D'Eustachio, Peter, 2022-05-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2024084
summation	[Summation:2065219] As part of the natural turnover of GAGs, extracellular HSPGs...
updateTrackers	[UpdateTracker:9953650] Update Tracker - [BlackBoxEvent:2024084] HS-GAGs translocate to the lysosome for degradation - v93:[modifyText, removeLiteratureReference, removeRegulator] [UpdateTracker:9847080] Update Tracker - [BlackBoxEvent:2024084] HS-GAGs translocate to the lysosome for degradation - v82:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953650] Update Tracker - [BlackBoxEvent:2024084] HS-GAGs translocate to the lysosome for degradation - v93:[modifyText, removeLiteratureReference, removeRegulator] [UpdateTracker:9847080] Update Tracker - [BlackBoxEvent:2024084] HS-GAGs translocate to the lysosome for degradation - v82:[modifyText]
(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)