Reactome | HS3ST2-6 sulfate GlcN at C3 in heparan sulfate

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HS3ST2-6 sulfate GlcN at C3 in heparan sulfate Show undefined attributes

authored	[InstanceEdit:2076352] Jassal, B, 2012-01-27
catalystActivity	[CatalystActivity:2076583] [heparan sulfate]-glucosamine 3-sulfotransferase activity of HS3ST2-6 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2076352] Jassal, B, 2012-01-27
crossReference	[DatabaseIdentifier:9941031] RHEA:15462
dbId	2076611
displayName	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate
edited	[InstanceEdit:2076352] Jassal, B, 2012-01-27
eventOf	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises - Homo sapiens [BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
input	[DefinedSet:R-HSA-2076297] HS(3)-PGs [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2076417] Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci [LiteratureReference:2076307] Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1 [LiteratureReference:2076400] Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate
orthologousEvent	[Reaction:R-BTA-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Bos taurus [Reaction:R-CEL-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Caenorhabditis elegans [Reaction:R-DME-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Drosophila melanogaster [Reaction:R-GGA-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Gallus gallus [Reaction:R-XTR-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Xenopus tropicalis [Reaction:R-DRE-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Danio rerio [Reaction:R-SSC-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Sus scrofa [Reaction:R-CFA-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Canis familiaris [Reaction:R-RNO-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Rattus norvegicus [Reaction:R-MMU-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-HSA-2076491] HS(4)-PGs [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate - Homo sapiens [Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2076611
summation	[Summation:2076478] Heparan sulfate 3-O-sulfotransferases (HS3ST2-6), associated...
updateTrackers	[UpdateTracker:9953708] Update Tracker - [Reaction:2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - v93:[removeOutput] [UpdateTracker:9774629] Update Tracker - [Reaction:2076611] HS3STs sulfate GlcN at C3 in heparan sulfate - v81:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953708] Update Tracker - [Reaction:2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - v93:[removeOutput] [UpdateTracker:9774629] Update Tracker - [Reaction:2076611] HS3STs sulfate GlcN at C3 in heparan sulfate - v81:[modifyText]
(hasEvent)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis
(precedingEvent)	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane [Reaction:R-HSA-2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises

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