Reactome | Some HSPGs are secreted to the plasma membrane

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Some HSPGs are secreted to the plasma membrane Show undefined attributes

category	omitted
compartment	[Compartment:17963] Golgi lumen [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10275033
displayName	Some HSPGs are secreted to the plasma membrane
eventOf	[Pathway:R-CFA-2022928] HS-GAG biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans - Canis familiaris [Reaction:R-CFA-9792569] proHPSE binds SDC1 - Canis familiaris [BlackBoxEvent:R-CFA-2024084] HS-GAGs translocate to the lysosome for degradation - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:160306] Golgi to plasma membrane protein transport
inferredFrom	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane - Homo sapiens
input	[DefinedSet:R-CFA-2076619] HSPGs [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Some HSPGs are secreted to the plasma membrane
output	[DefinedSet:R-CFA-2076618] HSPGs [plasma membrane]
precedingEvent	[Reaction:R-CFA-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Canis familiaris [Reaction:R-CFA-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate - Canis familiaris [Reaction:R-CFA-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Canis familiaris [Reaction:R-CFA-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Canis familiaris [Reaction:R-CFA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-2024108
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-CFA-1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans [Reaction:R-CFA-9792569] proHPSE binds SDC1 [BlackBoxEvent:R-CFA-2024084] HS-GAGs translocate to the lysosome for degradation
(inferredTo)	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane