Reactome | HS2ST1 sulfates IdoA at C2 in heparan sulfate

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HS2ST1 sulfates IdoA at C2 in heparan sulfate Show undefined attributes

authored	[InstanceEdit:2076352] Jassal, B, 2012-01-27
catalystActivity	[CatalystActivity:2076430] heparan sulfate 2-O-sulfotransferase activity of HS2ST1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2076352] Jassal, B, 2012-01-27
dbId	2076508
displayName	HS2ST1 sulfates IdoA at C2 in heparan sulfate
edited	[InstanceEdit:2076352] Jassal, B, 2012-01-27
eventOf	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2076611] HS3STs sulfate GlcN at C3 in heparan sulfate - Homo sapiens [Reaction:R-HSA-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Homo sapiens [BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:19673] heparan sulfate proteoglycan biosynthetic process, enzymatic modification
input	[DefinedSet:R-HSA-2076425] HS(2)-PGs [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2076546] Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation [LiteratureReference:2076599] Target selection of heparan sulfate hexuronic acid 2-O-sulfotransferase
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	HS2ST1 sulfates IdoA at C2 in heparan sulfate
orthologousEvent	[Reaction:R-CEL-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Caenorhabditis elegans [Reaction:R-DME-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Drosophila melanogaster [Reaction:R-GGA-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Gallus gallus [Reaction:R-XTR-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Xenopus tropicalis [Reaction:R-DRE-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Danio rerio [Reaction:R-SSC-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Sus scrofa [Reaction:R-BTA-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Bos taurus [Reaction:R-CFA-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Canis familiaris [Reaction:R-RNO-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Rattus norvegicus [Reaction:R-MMU-2076508] HS2ST1 sulfates IdoA at C2 in heparan sulfate - Mus musculus
output	[DefinedSet:R-HSA-2076297] HS(3)-PGs [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-2024100] GLCE epimerises GlcA to IdoA - Homo sapiens [Reaction:R-HSA-741449] SLC35B2,3 transport cytosolic PAPS to Golgi lumen - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2076508
summation	[Summation:2076509] Human heparan sulfate L-iduronyl 2-O-sulfotransferase 1 (HS2...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2024108] Some HSPGs are secreted to the plasma membrane [Reaction:R-HSA-2076611] HS3STs sulfate GlcN at C3 in heparan sulfate [Reaction:R-HSA-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate
(hasEvent)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis