Reactome | p-S939,T1462-TSC2 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

p-S939,T1462-TSC2 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Homo sapiens
created	[InstanceEdit:199481] Jassal, B, 2007-07-11 09:33:46
dbId	199484
displayName	p-S939,T1462-TSC2 [cytosol]
endCoordinate	1807
hasModifiedResidue	[ModifiedResidue:199480] O-phospho-L-serine at 939 [ModifiedResidue:199482] O-phospho-L-threonine at 1462
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-199484] phospho-Tsc2 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-199484] phospho-Tsc2 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-199484] phospho-TSC2 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-199484] phospho-p-S939,T1462-TSC2 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-199484] phospho-TSC2 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-199484] phospho-tsc2 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-199484] phospho-TSC2 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-199484] phospho-gig [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DDI-199484] phospho-p-S939,T1462-TSC2 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-199484] phospho-tsc2 [cytosol] - Schizosaccharomyces pombe
maxDepth	1
modified	[InstanceEdit:3325515] Orlic-Milacic, M, 2013-05-09
name	p-S939,T1462-TSC2 Phospho-TSC2
producedByEvent	[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - Homo sapiens [Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P49815] UniProt:P49815 TSC2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-199484
startCoordinate	1
updateTrackers	[UpdateTracker:9873176] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v42:[addEndCoordinate, addStartCoordinate] [UpdateTracker:9870243] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v38:[addName] [UpdateTracker:9876130] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v44:[add_removeReferenceEntity, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9873176] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v42:[addEndCoordinate, addStartCoordinate] [UpdateTracker:9870243] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v38:[addName] [UpdateTracker:9876130] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v44:[add_removeReferenceEntity, modifyName]
(output)	[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it [Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it
(hasComponent)	[Complex:R-HSA-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol]
(input)	[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

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