Reactome | phospho-p-S939,T1462-TSC2 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DDI-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol] - Dictyostelium discoideum
consumedByEvent	[Reaction:R-DDI-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Dictyostelium discoideum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11005962
displayName	phospho-p-S939,T1462-TSC2 [cytosol]
endCoordinate	1807
hasModifiedResidue	[ModifiedResidue:11003558] O-phospho-L-serine at 939 (in Homo sapiens) [ModifiedResidue:11003560] O-phospho-L-threonine at 1462 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-199484] p-S939,T1462-TSC2 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-S939,T1462-TSC2 Q54VB2
producedByEvent	[Reaction:R-DDI-198609] AKT phosphorylates TSC2, inhibiting it - Dictyostelium discoideum
referenceEntity	[ReferenceGeneProduct:uniprot:Q54VB2] UniProt:Q54VB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-199484
startCoordinate	1

(input)	[Reaction:R-DDI-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
(hasComponent)	[Complex:R-DDI-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol]
(output)	[Reaction:R-DDI-198609] AKT phosphorylates TSC2, inhibiting it
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-199484] p-S939,T1462-TSC2 [cytosol]

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