Reactome | Transport of fringe-modified NOTCH to plasma membrane

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Transport of fringe-modified NOTCH to plasma membrane Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1912380] Orlic-Milacic, M, 2011-11-01
dbId	1912379
deleted	[Deleted:6792898] Deletion of instance: 157128 [Deleted:5694741] Deletion of instance: 157117 [Deleted:5694727] Deletion of instance: 157151 [Deleted:5694732] Deletion of instance: 157076 [Deleted:5694733] Deletion of instance: 157000
displayName	Transport of fringe-modified NOTCH to plasma membrane
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi - Homo sapiens
followingEvent	[Reaction:R-HSA-1980048] DLL1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980056] JAG1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH - Homo sapiens [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 - Homo sapiens [Reaction:R-HSA-1980041] NOTCH1 binds DLL4 - Homo sapiens
input	[CandidateSet:R-HSA-1911547] FRINGE-modified NOTCH [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Transport of fringe-modified NOTCH to plasma membrane
orthologousEvent	[BlackBoxEvent:R-GGA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Gallus gallus [BlackBoxEvent:R-XTR-1912379] Transport of fringe-modified NOTCH to plasma membrane - Xenopus tropicalis [BlackBoxEvent:R-MMU-1912379] Transport of fringe-modified NOTCH to plasma membrane - Mus musculus
output	[CandidateSet:R-HSA-1911550] Fringe-modified NOTCH [plasma membrane]
precedingEvent	[Reaction:R-HSA-1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-2043098] Negative regulation by 'TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]'
regulationReference	[RegulationReference:9642124] Negative regulation by 'TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]' p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912379
summation	[Summation:2043100] Fringe-modified NOTCH functions at the plasma membrane. The ...

Referrals

(replacementInstances)	[Deleted:6792898] Deletion of instance: 157128 [Deleted:5694741] Deletion of instance: 157117 [Deleted:5694727] Deletion of instance: 157151 [Deleted:5694732] Deletion of instance: 157076 [Deleted:5694733] Deletion of instance: 157000
(precedingEvent)	[Reaction:R-HSA-1980048] DLL1 binds NOTCH2 [Reaction:R-HSA-1980056] JAG1 binds NOTCH2 [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 [Reaction:R-HSA-1980041] NOTCH1 binds DLL4
(hasEvent)	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi