Reactome | Phosphorylation of beta-catenin at Ser45 by CK1 alpha

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Phosphorylation of beta-catenin at Ser45 by CK1 alpha Show undefined attributes

authored	[InstanceEdit:195289] Kimelman, D, 2007-04-03 12:34:14
catalystActivity	[CatalystActivity:1505509] protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
dbId	195318
diseaseReaction	[FailedReaction:R-HSA-4827388] CTNNB1 S45 mutants aren't phosphorylated by CK1alpha - Homo sapiens
displayName	Phosphorylation of beta-catenin at Ser45 by CK1 alpha
edited	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
eventOf	[Pathway:R-HSA-196299] Beta-catenin phosphorylation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196269] Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of beta-catenin at Ser45 by CK1 alpha
orthologousEvent	[Reaction:R-CEL-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Caenorhabditis elegans [Reaction:R-DME-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Drosophila melanogaster [Reaction:R-GGA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Gallus gallus [Reaction:R-XTR-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Xenopus tropicalis [Reaction:R-DRE-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Danio rerio [Reaction:R-SSC-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Sus scrofa [Reaction:R-BTA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Bos taurus [Reaction:R-CFA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Canis familiaris [Reaction:R-RNO-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Rattus norvegicus [Reaction:R-MMU-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196987] Pagano, M, 2007-04-27 13:02:18
revised	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5433076] Salahshor, S, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-195318
summation	[Summation:196301] CK1a binds to Axin and phosphorylates beta-catenin at Ser45 ...
updateTrackers	[UpdateTracker:9782069] Update Tracker - [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - v59:[add_removeInput] [UpdateTracker:9788781] Update Tracker - [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - v40:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9782069] Update Tracker - [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - v59:[add_removeInput] [UpdateTracker:9788781] Update Tracker - [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - v40:[add_removeCatalystActivity]
(normalReaction)	[FailedReaction:R-HSA-4827388] CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
(hasEvent)	[Pathway:R-HSA-196299] Beta-catenin phosphorylation cascade
(precedingEvent)	[Reaction:R-HSA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3

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