Reactome | p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

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p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:196226] protein serine/threonine kinase activity of p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 - Homo sapiens
created	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
dbId	195277
displayName	p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
hasComponent	[Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [EntityWithAccessionedSequence:R-HSA-8942363] p-S45 CTNNB1 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Mus musculus [Complex:R-RNO-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Rattus norvegicus [Complex:R-CFA-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Canis familiaris [Complex:R-BTA-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Bos taurus [Complex:R-SSC-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Sus scrofa [Complex:R-DRE-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Danio rerio [Complex:R-XTR-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Xenopus tropicalis [Complex:R-GGA-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Gallus gallus [Complex:R-DME-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Drosophila melanogaster [Complex:R-CEL-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Caenorhabditis elegans
maxDepth	5
modified	[InstanceEdit:8943894] Rothfels, Karen, 2016-10-31
name	p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex pS45-beta-catenin:destruction complex
producedByEvent	[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-195277
updateTrackers	[UpdateTracker:9871595] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v40:[modifyName, updateContainedComponent] [UpdateTracker:9870746] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v38:[updateContainedComponent] [UpdateTracker:9874275] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v43:[updateContainedComponent] [UpdateTracker:9895169] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v59:[add_removeHasComponent, modifyName] [UpdateTracker:9871378] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v39:[updateContainedComponent] [UpdateTracker:9889161] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v48:[add_removeHasComponent, modifyName] [UpdateTracker:9889647] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent] [UpdateTracker:9868034] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v28:[updateContainedComponent] [UpdateTracker:9888699] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v47:[modifyName, updateContainedComponent] [UpdateTracker:9878394] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v44:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9871595] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v40:[modifyName, updateContainedComponent] [UpdateTracker:9870746] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v38:[updateContainedComponent] [UpdateTracker:9874275] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v43:[updateContainedComponent] [UpdateTracker:9895169] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v59:[add_removeHasComponent, modifyName] [UpdateTracker:9871378] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v39:[updateContainedComponent] [UpdateTracker:9889161] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v48:[add_removeHasComponent, modifyName] [UpdateTracker:9889647] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent] [UpdateTracker:9868034] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v28:[updateContainedComponent] [UpdateTracker:9888699] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v47:[modifyName, updateContainedComponent] [UpdateTracker:9878394] Update Tracker - [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v44:[updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:4839615] loss_of_function of pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] [EntityFunctionalStatus:5339702] loss_of_function of pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
(output)	[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha
(input)	[Reaction:R-HSA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
(physicalEntity)	[CatalystActivity:196226] protein serine/threonine kinase activity of p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

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