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Schema
>
FailedReaction
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Entries
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
Show undefined attributes
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authored
[InstanceEdit:5358807] Rothfels, Karen, 2014-04-03
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:4827389] Rothfels, K, 2013-10-29
dbId
4827388
disease
[Disease:1500689] cancer
displayName
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
edited
[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus
[EntityFunctionalStatus:4827390] loss_of_function of CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
eventOf
[Pathway:R-HSA-5358751] CTNNB1 S45 mutants aren't phosphorylated - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-4827387] CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:196269] Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
[LiteratureReference:5246621] Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
[LiteratureReference:5251485] Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
[LiteratureReference:5251529] Nuclear accumulation of beta-catenin protein in Wilms' tumours
[LiteratureReference:5246618] Wnt signaling and cancer
[LiteratureReference:5251531] Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
normalReaction
[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5433076] Salahshor, S, 2014-05-12
[InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4827388
summation
[Summation:5251527] Missense or deletion mutations at Ser45 abolish the CK1alpha...
Referrals
(hasEvent)
[Pathway:R-HSA-5358751] CTNNB1 S45 mutants aren't phosphorylated
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