Phosphorylation of beta-catenin at Ser45 by CK1 alpha

Stable Identifier
R-HSA-195318
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Phosphorylation of beta-catenin at Ser45 by CK1 alpha
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CK1a binds to Axin and phosphorylates beta-catenin at Ser45 priming GSK3 mediated phosphorylation at the more N-terminal residues (Amit et al., 2002; Liu et al., 2002; Yanagawa et al., 2002).

Literature References
PubMed ID Title Journal Year
12000790 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

Amit, S, Hatzubai, A, Birman, Y, Andersen, JS, Ben-Shushan, E, Mann, M, Ben-Neriah, Y, Alkalay, I

Genes Dev 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Physical Entity
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Danio rerio)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Sus scrofa)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Xenopus tropicalis)
Authored
Kimelman, D  (2007-04-03)
Reviewed
Pagano, M  (2007-04-27)
Created
Matthews, L  (2007-04-03)