Reactome | CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

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CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:1505509] protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Homo sapiens
created	[InstanceEdit:3601582] Rothfels, K, 2013-05-22
dbId	3601581
deleted	[Deleted:8944409] Deletion of instance: 195301
displayName	CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-448839] CTNNB1 [cytosol] [Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Mus musculus [Complex:R-RNO-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Rattus norvegicus [Complex:R-CFA-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Canis familiaris [Complex:R-BTA-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Bos taurus [Complex:R-SSC-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Sus scrofa [Complex:R-DRE-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Danio rerio [Complex:R-XTR-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Xenopus tropicalis [Complex:R-GGA-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Gallus gallus [Complex:R-DME-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Drosophila melanogaster [Complex:R-CEL-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Caenorhabditis elegans
maxDepth	5
modified	[InstanceEdit:5492221] Rothfels, Karen, 2014-05-20
name	CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex CTNNB1:destruction complex beta-catenin:destruction complex
producedByEvent	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3601581
updateTrackers	[UpdateTracker:9889725] Update Tracker - [Complex:3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9889725] Update Tracker - [Complex:3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent]
(replacementInstances)	[Deleted:8944409] Deletion of instance: 195301
(normalEntity)	[EntityFunctionalStatus:4827390] loss_of_function of CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
(output)	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex
(input)	[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha
(physicalEntity)	[CatalystActivity:1505509] protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

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