Reactome | Phosphorylation of beta-catenin at Ser45 by CK1 alpha

Schema > Reaction > Entries

Phosphorylation of beta-catenin at Ser45 by CK1 alpha Show undefined attributes

catalystActivity	[CatalystActivity:10002129] protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002131
displayName	Phosphorylation of beta-catenin at Ser45 by CK1 alpha
eventOf	[Pathway:R-MMU-196299] Beta-catenin phosphorylation cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 - Mus musculus
inferredFrom	[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of beta-catenin at Ser45 by CK1 alpha
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-MMU-195304] Association of beta-catenin with the destruction complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-195318
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196299] Beta-catenin phosphorylation cascade
(precedingEvent)	[Reaction:R-MMU-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
(inferredTo)	[Reaction:R-HSA-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha

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