Reactome | Association of beta-catenin with the destruction complex

Schema > Reaction > Entries

Association of beta-catenin with the destruction complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10927135
displayName	Association of beta-catenin with the destruction complex
eventOf	[Pathway:R-CEL-195253] Degradation of beta-catenin by the destruction complex - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-CEL-448839] hmp-2 [cytosol] [Complex:R-CEL-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Association of beta-catenin with the destruction complex
output	[Complex:R-CEL-3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-CEL-5229343] AXIN is phosphorylated in the destruction complex - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-195304
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-CEL-195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha
(inferredTo)	[Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex

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