Reactome | CYP51A1 demethylates LAN

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CYP51A1 demethylates LAN Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:194693] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen of CYP51A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
crossReference	[DatabaseIdentifier:9907888] RHEA:25287
dbId	194678
displayName	CYP51A1 demethylates LAN
edited	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
eventOf	[Pathway:R-HSA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Homo sapiens [Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent	[Reaction:R-HSA-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] - Homo sapiens [Reaction:R-HSA-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] - Homo sapiens [Reaction:R-HSA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Homo sapiens
input	3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-194634] LAN [endoplasmic reticulum membrane] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194658] The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols [LiteratureReference:5602275] Structural basis of human CYP51 inhibition by antifungal azoles
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CYP51A1 demethylates LAN lanosterol + 3 O2 + 3 reduced (NADPH--hemoprotein reductase) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized (NADPH--hemoprotein reductase) lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate
orthologousEvent	[Reaction:R-SCE-194678] CYP51A1 demethylates LAN - Saccharomyces cerevisiae [Reaction:R-SPO-194678] CYP51A1 demethylates LAN - Schizosaccharomyces pombe [Reaction:R-DDI-194678] CYP51A1 demethylates LAN - Dictyostelium discoideum [Reaction:R-GGA-194678] CYP51A1 demethylates LAN - Gallus gallus [Reaction:R-DRE-194678] CYP51A1 demethylates LAN - Danio rerio [Reaction:R-SSC-194678] CYP51A1 demethylates LAN - Sus scrofa [Reaction:R-BTA-194678] CYP51A1 demethylates LAN - Bos taurus [Reaction:R-CFA-194678] CYP51A1 demethylates LAN - Canis familiaris [Reaction:R-RNO-194678] CYP51A1 demethylates LAN - Rattus norvegicus [Reaction:R-MMU-194678] CYP51A1 demethylates LAN - Mus musculus
output	[SimpleEntity:R-ALL-194644] 4,4DMCHtOL [endoplasmic reticulum membrane] 4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194678
summation	[Summation:194660] Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidativ...
updateTrackers	[UpdateTracker:9971812] Update Tracker - [Reaction:194678] CYP51A1 demethylates LAN - v95:[modifyText] [UpdateTracker:9786284] Update Tracker - [Reaction:194678] CYP51A1 demethylates LNSOL - v50:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9971812] Update Tracker - [Reaction:194678] CYP51A1 demethylates LAN - v95:[modifyText] [UpdateTracker:9786284] Update Tracker - [Reaction:194678] CYP51A1 demethylates LNSOL - v50:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-211976] Endogenous sterols [Pathway:R-HSA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-HSA-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] [Reaction:R-HSA-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] [Reaction:R-HSA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol