Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidative C14-demethylation of lanosterol (LNSOL) to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol (4,4DMCHOLtrienol). Although the reaction is annotated here as a single concerted event, studies with purified rat enzyme indicate that the methyl group is converted successively to an alcohol and an aldehyde before being released as formate (Stromstedt et al. 1996, Strushkevich et al. 2010).
Park, HW, Usanov, SA, Strushkevich, N
Stromstedt, M, Waterman, MR, Rozman, D
sterol 14-demethylase activity of CYP51A1 [endoplasmic reticulum membrane]
© 2023 Reactome
