Reactome | Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidativ...

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created	[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
dbId	194660
displayName	Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidativ...
literatureReference	[LiteratureReference:194651] Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate. [LiteratureReference:194654] Microsomal enzymes of cholesterol biosynthesis. Purification of lanosterol 14 alpha-methyl demethylase cytochrome P-450 from hepatic microsomes. [LiteratureReference:194670] Membrane-bound enzymes of cholesterol synthesis from lanosterol
modified	[InstanceEdit:9969571] D'Eustachio, Peter, 2025-10-22
schemaClass	Summation
text	Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidative C14-demethylation of lanosterol (LAN) to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol (4,4DMCHOLtrienol). Although the reaction is annotated here as a single concerted event, studies with purified rat enzyme indicate that the methyl group is converted successively to an alcohol and an aldehyde before being released as formate (Stromstedt et al. 1996, Strushkevich et al. 2010).

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