Reactome | Squalene 2,3-epoxide cyclizes, forming lanosterol

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Squalene 2,3-epoxide cyclizes, forming lanosterol Show undefined attributes

authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191416] lanosterol synthase activity of LSS [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:12668095] RHEA:14621 [DatabaseIdentifier:9945096] RHEA:14622
dbId	191366
displayName	Squalene 2,3-epoxide cyclizes, forming lanosterol
eventOf	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-194678] CYP51A1 demethylates LAN - Homo sapiens [Reaction:R-HSA-9755937] DHCR24 reduces LAN to 24,25-dhLAN - Homo sapiens
input	[SimpleEntity:R-ALL-191309] SQOX [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191360] The monotopic membrane protein human oxidosqualene cyclase is active as monomer [LiteratureReference:191357] Molecular cloning of cDNA encoding human lanosterol synthase [LiteratureReference:191399] Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Squalene 2,3-epoxide cyclizes, forming lanosterol (S)-2,3-epoxysqualene => lanosterol
orthologousEvent	[Reaction:R-SCE-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Saccharomyces cerevisiae [Reaction:R-SPO-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Schizosaccharomyces pombe [Reaction:R-DDI-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Dictyostelium discoideum [Reaction:R-GGA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Gallus gallus [Reaction:R-XTR-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Xenopus tropicalis [Reaction:R-DRE-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Danio rerio [Reaction:R-SSC-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Sus scrofa [Reaction:R-BTA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Bos taurus [Reaction:R-CFA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Canis familiaris [Reaction:R-RNO-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Rattus norvegicus [Reaction:R-MMU-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Mus musculus
output	[SimpleEntity:R-ALL-194634] LAN [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-191299] Squalene is oxidized to its epoxide - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191366
summation	[Summation:191288] Lanosterol synthase (LSS) catalyzes the cyclization of squal...
updateTrackers	[UpdateTracker:9776602] Update Tracker - [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - v75:[modifyText] [UpdateTracker:9791018] Update Tracker - [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - v32:[add_removeOutput] [UpdateTracker:9971885] Update Tracker - [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - v95:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9776602] Update Tracker - [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - v75:[modifyText] [UpdateTracker:9791018] Update Tracker - [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - v32:[add_removeOutput] [UpdateTracker:9971885] Update Tracker - [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - v95:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-HSA-194678] CYP51A1 demethylates LAN [Reaction:R-HSA-9755937] DHCR24 reduces LAN to 24,25-dhLAN

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