Reactome | Cholesterol biosynthesis via desmosterol (Bloch pathway)

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Cholesterol biosynthesis via desmosterol (Bloch pathway) Show undefined attributes

authored	[InstanceEdit:6807519] D'Eustachio, Peter, 2015-11-02
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6807046] D'Eustachio, Peter, 2015-10-28
dbId	6807047
displayName	Cholesterol biosynthesis via desmosterol (Bloch pathway)
doi	10.3180/R-HSA-6807047.3
edited	[InstanceEdit:6807519] D'Eustachio, Peter, 2015-11-02
eventOf	[Pathway:R-HSA-191273] Cholesterol biosynthesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20521] cholesterol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-194678] CYP51A1 demethylates LAN - Homo sapiens [Reaction:R-HSA-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] - Homo sapiens [Reaction:R-HSA-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] - Homo sapiens [Reaction:R-HSA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Homo sapiens [Reaction:R-HSA-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Homo sapiens [Reaction:R-HSA-194689] 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol - Homo sapiens [Reaction:R-HSA-194669] 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol - Homo sapiens [Reaction:R-HSA-194718] 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) - Homo sapiens [Reaction:R-HSA-194632] Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) - Homo sapiens [Reaction:R-HSA-195690] Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol - Homo sapiens [Reaction:R-HSA-195664] Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol - Homo sapiens [Reaction:R-HSA-196402] Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol - Homo sapiens [Reaction:R-HSA-196417] Reduction of desmosterol to cholesterol - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6807060] Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Cholesterol biosynthesis via desmosterol (Bloch pathway)
orthologousEvent	[Pathway:R-BTA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Bos taurus [Pathway:R-SCE-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Saccharomyces cerevisiae [Pathway:R-SPO-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Schizosaccharomyces pombe [Pathway:R-DDI-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Dictyostelium discoideum [Pathway:R-CEL-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Caenorhabditis elegans [Pathway:R-DME-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Drosophila melanogaster [Pathway:R-GGA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Gallus gallus [Pathway:R-XTR-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Xenopus tropicalis [Pathway:R-DRE-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Danio rerio [Pathway:R-SSC-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Sus scrofa [Pathway:R-CFA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Canis familiaris [Pathway:R-RNO-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Rattus norvegicus [Pathway:R-MMU-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Mus musculus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6807520] Jassal, Bijay, 2015-11-02 [InstanceEdit:9969910] Hill, David P, 2025-10-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6807047
summation	[Summation:6807065] The transformation of zymosterol into cholesterol can follow...
updateTrackers	[UpdateTracker:9971890] Update Tracker - [Pathway:6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - v95:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9971890] Update Tracker - [Pathway:6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - v95:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-191273] Cholesterol biosynthesis

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