Reactome | CYP51A1 demethylates LAN

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CYP51A1 demethylates LAN Show undefined attributes

catalystActivity	[CatalystActivity:10002025] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen of CYP51A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002027
displayName	CYP51A1 demethylates LAN
eventOf	[Pathway:R-MMU-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Mus musculus [Pathway:R-MMU-211976] Endogenous sterols - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] - Mus musculus [Reaction:R-MMU-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Mus musculus [Reaction:R-MMU-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] - Mus musculus
inferredFrom	[Reaction:R-HSA-194678] CYP51A1 demethylates LAN - Homo sapiens
input	3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-194634] LAN [endoplasmic reticulum membrane] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP51A1 demethylates LAN lanosterol + 3 O2 + 3 reduced (NADPH--hemoprotein reductase) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized (NADPH--hemoprotein reductase) lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate
output	[SimpleEntity:R-ALL-194644] 4,4DMCHtOL [endoplasmic reticulum membrane] 4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-194678
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-211976] Endogenous sterols [Pathway:R-MMU-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-MMU-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] [Reaction:R-MMU-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol [Reaction:R-MMU-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]
(inferredTo)	[Reaction:R-HSA-194678] CYP51A1 demethylates LAN

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