Reactome | 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol

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4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol Show undefined attributes

authored	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
catalystActivity	[CatalystActivity:194699] C-4 methylsterol oxidase activity of MSMO1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
crossReference	[DatabaseIdentifier:9969572] RHEA:55245
dbId	194641
displayName	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol
edited	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
eventOf	[Pathway:R-HSA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Homo sapiens
followingEvent	[Reaction:R-HSA-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Homo sapiens
input	[SimpleEntity:R-ALL-194633] 14DMLANOL [endoplasmic reticulum membrane] 3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194692] Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
orthologousEvent	[Reaction:R-SCE-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Saccharomyces cerevisiae [Reaction:R-SPO-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Schizosaccharomyces pombe [Reaction:R-DDI-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Dictyostelium discoideum [Reaction:R-GGA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Gallus gallus [Reaction:R-XTR-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Xenopus tropicalis [Reaction:R-DRE-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Danio rerio [Reaction:R-SSC-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Sus scrofa [Reaction:R-BTA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Bos taurus [Reaction:R-CFA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Canis familiaris [Reaction:R-RNO-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Rattus norvegicus [Reaction:R-MMU-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Mus musculus
output	[SimpleEntity:R-ALL-194735] 4C4MZYMOL [endoplasmic reticulum membrane] 4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-194678] CYP51A1 demethylates LAN - Homo sapiens [Reaction:R-HSA-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196409] Jassal, B, 2007-04-21 18:33:24 [InstanceEdit:9969577] Hill, David P, 2025-10-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194641
summation	[Summation:194733] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol, NADPH + H+, and...
updateTrackers	[UpdateTracker:9971952] Update Tracker - [Reaction:194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - v95:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9971952] Update Tracker - [Reaction:194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - v95:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-HSA-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one