Reactome | Fringe-modified Pre-NOTCH is cleaved by FURIN

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Fringe-modified Pre-NOTCH is cleaved by FURIN Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:1912373] Orlic-Milacic, M, 2011-11-01
dbId	1912372
deleted	[Deleted:5694730] Deletion of instance: 156994 [Deleted:5694734] Deletion of instance: 157131 [Deleted:5694740] Deletion of instance: 157013 [Deleted:5694737] Deletion of instance: 157042
displayName	Fringe-modified Pre-NOTCH is cleaved by FURIN
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Homo sapiens
input	[CandidateSet:R-HSA-1911509] Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch [LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane [LiteratureReference:2153479] Sorting of furin at the trans-Golgi network. Interaction of the cytoplasmic tail sorting signals with AP-1 Golgi-specific assembly proteins
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Fringe-modified Pre-NOTCH is cleaved by FURIN
orthologousEvent	[Reaction:R-GGA-1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN - Gallus gallus [Reaction:R-XTR-1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN - Xenopus tropicalis [Reaction:R-MMU-1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN - Mus musculus
output	[CandidateSet:R-HSA-1911547] FRINGE-modified NOTCH [Golgi membrane]
precedingEvent	[Reaction:R-HSA-1912378] Sialylation of Pre-NOTCH - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1912372
summation	[Summation:2043101] Cleavage of fringe-modified NOTCH by FURIN has not been exam...

Referrals

(replacementInstances)	[Deleted:5694730] Deletion of instance: 156994 [Deleted:5694734] Deletion of instance: 157131 [Deleted:5694740] Deletion of instance: 157013 [Deleted:5694737] Deletion of instance: 157042
(hasEvent)	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi
(precedingEvent)	[BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane

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