Reactome | Glycosylation of Pre-NOTCH by FRINGE

Schema > Reaction > Entries

Glycosylation of Pre-NOTCH by FRINGE Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:1464793] O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity of Fringe family [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1912356] Orlic-Milacic, M, 2011-11-01
dbId	1912355
diseaseReaction	[FailedReaction:R-HSA-5096538] Defective LFNG does not transfer GlcNAc to Pre-NOTCH - Homo sapiens
displayName	Glycosylation of Pre-NOTCH by FRINGE
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi - Homo sapiens
followingEvent	[Reaction:R-HSA-1912352] Galactosylation of Pre-NOTCH - Homo sapiens
inferredFrom	[Reaction:R-MMU-2023158] Glycosylation of Pre-Notch by Fringe - Mus musculus
input	[CandidateSet:R-HSA-1911440] Glc,Fuc-Pre-NOTCH [Golgi membrane] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1602189] Glycosyltransferase activity of Fringe modulates Notch-Delta interactions [LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch [LiteratureReference:2152308] Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila [LiteratureReference:2023165] A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway [LiteratureReference:2127649] Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed ?? T-cell progenitors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Glycosylation of Pre-NOTCH by FRINGE
output	[CandidateSet:R-HSA-1911434] Glc,GlcNAc-Fuc-Pre-NOTCH [Golgi membrane] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[BlackBoxEvent:R-HSA-1912374] Transport of NOTCH precursor to Golgi - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1912355
summation	[Summation:2023175] The Fringe family (CAZy family GT31) of glycosyltransferases...
updateTrackers	[UpdateTracker:9783563] Update Tracker - [Reaction:1912355] Glycosylation of Pre-NOTCH by FRINGE - v56:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783563] Update Tracker - [Reaction:1912355] Glycosylation of Pre-NOTCH by FRINGE - v56:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5096538] Defective LFNG does not transfer GlcNAc to Pre-NOTCH
(hasEvent)	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi
(precedingEvent)	[Reaction:R-HSA-1912352] Galactosylation of Pre-NOTCH
(inferredTo)	[Reaction:R-MMU-2023158] Glycosylation of Pre-Notch by Fringe