Reactome | Transport of NOTCH precursor to Golgi

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Transport of NOTCH precursor to Golgi Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
category	omitted
compartment	[Compartment:20699] Golgi membrane [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1912376] Orlic-Milacic, M, 2011-11-01
dbId	1912374
deleted	[Deleted:5694735] Deletion of instance: 156990 [Deleted:5694738] Deletion of instance: 157034 [Deleted:9034328] Deletion of instance: 157119 [Deleted:5694736] Deletion of instance: 157077 [Deleted:5694739] Deletion of instance: 157144
displayName	Transport of NOTCH precursor to Golgi
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi - Homo sapiens
followingEvent	[Reaction:R-HSA-1912355] Glycosylation of Pre-NOTCH by FRINGE - Homo sapiens [Reaction:R-HSA-1912369] NOTCH precursor cleaved to form mature NOTCH - Homo sapiens
inferredFrom	[Reaction:R-DME-2032746] Rab6 positively regulates Notch trafficking through Golgi - Drosophila melanogaster [Reaction:R-MMU-2032750] Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum - Mus musculus [BlackBoxEvent:R-DME-1984022] Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking - Drosophila melanogaster
input	[CandidateSet:R-HSA-1911442] Glc,Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:157105] The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium [LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane [LiteratureReference:157153] A homolog of Drosophila Notch expressed during mammalian development [LiteratureReference:157055] Notch2: a second mammalian Notch gene [LiteratureReference:157003] Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene [LiteratureReference:1602209] The developmental role of warthog, the notch modifier encoding Drab6 [LiteratureReference:2032754] SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells [LiteratureReference:2032749] Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans [LiteratureReference:2032748] Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality [LiteratureReference:1602198] Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transport of NOTCH precursor to Golgi
output	[CandidateSet:R-HSA-1911440] Glc,Fuc-Pre-NOTCH [Golgi membrane]
precedingEvent	[Reaction:R-HSA-1912353] Glucosylation of Pre-NOTCH by POGLUT1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-1980098] Positive regulation by 'RAB6A [Golgi membrane]' [NegativeRegulation:R-HSA-1980101] Negative regulation by 'SEL1L [endoplasmic reticulum membrane]' [PositiveRegulation:R-HSA-1980104] Positive regulation by 'ATP2A1-3 [endoplasmic reticulum membrane]'
regulationReference	[RegulationReference:9641436] Negative regulation by 'SEL1L [endoplasmic reticulum membrane]' The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein [RegulationReference:9641597] Positive regulation by 'ATP2A1-3 [endoplasmic reticulum membrane]' Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila [RegulationReference:9642941] Positive regulation by 'RAB6A [Golgi membrane]' The developmental role of warthog, the notch modifier encoding Drab6
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1912374
summation	[Summation:1912375] NOTCH receptor precursors (Pre-NOTCH) traffic from the endop...
updateTrackers	[UpdateTracker:9775795] Update Tracker - [BlackBoxEvent:1912374] Transport of NOTCH precursor to Golgi - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775795] Update Tracker - [BlackBoxEvent:1912374] Transport of NOTCH precursor to Golgi - v78:[modifyText]
(replacementInstances)	[Deleted:5694735] Deletion of instance: 156990 [Deleted:5694738] Deletion of instance: 157034 [Deleted:9034328] Deletion of instance: 157119 [Deleted:5694736] Deletion of instance: 157077 [Deleted:5694739] Deletion of instance: 157144
(hasEvent)	[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi
(precedingEvent)	[Reaction:R-HSA-1912355] Glycosylation of Pre-NOTCH by FRINGE [Reaction:R-HSA-1912369] NOTCH precursor cleaved to form mature NOTCH
(inferredTo)	[BlackBoxEvent:R-DME-1984022] Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking [Reaction:R-DME-2032746] Rab6 positively regulates Notch trafficking through Golgi [Reaction:R-MMU-2032750] Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum

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