Reactome | Activation of ATR in response to replication stress

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Activation of ATR in response to replication stress Show undefined attributes

authored	[InstanceEdit:176227] Borowiec, JA, 2006-02-25 17:40:15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
crossReference	[DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939
dbId	176187
displayName	Activation of ATR in response to replication stress
edited	[InstanceEdit:176160] D'Eustachio, P, 2006-02-25 17:41:28
eventOf	[Pathway:R-HSA-69481] G2/M Checkpoints - Homo sapiens
figure	[Figure:176321] /figures/ATR_loading.jpg
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-176175] Stalling of DNA replication fork and RPA binding - Homo sapiens [Reaction:R-HSA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex - Homo sapiens [Reaction:R-HSA-176101] Recruitment of Rad17-RFC complex to DNA - Homo sapiens [Reaction:R-HSA-176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA - Homo sapiens [Reaction:R-HSA-176318] Loading of claspin onto DNA during replication origin firing - Homo sapiens [Reaction:R-HSA-176298] Activation of claspin - Homo sapiens [Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens [Reaction:R-HSA-69604] Phosphorylation of CDC25A by CHEK1 - Homo sapiens [Reaction:R-HSA-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2014-07-15
literatureReference	[LiteratureReference:176216] Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activation of ATR in response to replication stress
orthologousEvent	[Pathway:R-SCE-176187] Activation of ATR in response to replication stress - Saccharomyces cerevisiae [Pathway:R-SPO-176187] Activation of ATR in response to replication stress - Schizosaccharomyces pombe [Pathway:R-DDI-176187] Activation of ATR in response to replication stress - Dictyostelium discoideum [Pathway:R-CEL-176187] Activation of ATR in response to replication stress - Caenorhabditis elegans [Pathway:R-DME-176187] Activation of ATR in response to replication stress - Drosophila melanogaster [Pathway:R-GGA-176187] Activation of ATR in response to replication stress - Gallus gallus [Pathway:R-XTR-176187] Activation of ATR in response to replication stress - Xenopus tropicalis [Pathway:R-DRE-176187] Activation of ATR in response to replication stress - Danio rerio [Pathway:R-SSC-176187] Activation of ATR in response to replication stress - Sus scrofa [Pathway:R-BTA-176187] Activation of ATR in response to replication stress - Bos taurus [Pathway:R-CFA-176187] Activation of ATR in response to replication stress - Canis familiaris [Pathway:R-RNO-176187] Activation of ATR in response to replication stress - Rattus norvegicus [Pathway:R-MMU-176187] Activation of ATR in response to replication stress - Mus musculus
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-176187
summation	[Summation:176245] Genotoxic stress caused by DNA damage or stalled replication...
updateTrackers	[UpdateTracker:9786466] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v49:[modifyText] [UpdateTracker:9789840] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v37:[modifyText] [UpdateTracker:9789131] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v38:[updateContainedRLE] [UpdateTracker:9791681] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v27:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9786466] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v49:[modifyText]
[UpdateTracker:9789840] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v37:[modifyText]
[UpdateTracker:9789131] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v38:[updateContainedRLE]
[UpdateTracker:9791681] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v27:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-69481] G2/M Checkpoints

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