Reactome | Activation of ATR in response to replication stress

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729282
displayName	Activation of ATR in response to replication stress
eventOf	[Pathway:R-XTR-69481] G2/M Checkpoints - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-176187] Activation of ATR in response to replication stress - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of ATR in response to replication stress
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-176187
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-69481] G2/M Checkpoints
(inferredTo)	[Pathway:R-HSA-176187] Activation of ATR in response to replication stress

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