Reactome | Activation of ATR in response to replication stress

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Activation of ATR in response to replication stress Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648418
displayName	Activation of ATR in response to replication stress
eventOf	[Pathway:R-DRE-69481] G2/M Checkpoints - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-176175] Stalling of DNA replication fork and RPA binding - Danio rerio [Reaction:R-DRE-176101] Recruitment of Rad17-RFC complex to DNA - Danio rerio [Reaction:R-DRE-176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA - Danio rerio
inferredFrom	[Pathway:R-HSA-176187] Activation of ATR in response to replication stress - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of ATR in response to replication stress
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-176187
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-69481] G2/M Checkpoints
(inferredTo)	[Pathway:R-HSA-176187] Activation of ATR in response to replication stress

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