Reactome | Phosphorylation of Cdc25C at Ser 216 by Chk1

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Phosphorylation of Cdc25C at Ser 216 by Chk1 Show undefined attributes

authored	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
catalystActivity	[CatalystActivity:182636] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
dbId	75010
displayName	Phosphorylation of Cdc25C at Ser 216 by Chk1
edited	[InstanceEdit:182637] Matthews, L, 2006-07-10 19:19:59
eventOf	[Pathway:R-HSA-176187] Activation of ATR in response to replication stress - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9029987] p-S216-CDC25C translocates to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-69741] CDC25C [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:75011] Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. [LiteratureReference:9941611] Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylation of Cdc25C at Ser 216 by Chk1
orthologousEvent	[Reaction:R-SCE-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Saccharomyces cerevisiae [Reaction:R-SPO-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Schizosaccharomyces pombe [Reaction:R-DDI-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Dictyostelium discoideum [Reaction:R-CEL-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Caenorhabditis elegans [Reaction:R-DME-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Drosophila melanogaster [Reaction:R-SSC-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Sus scrofa [Reaction:R-CFA-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Canis familiaris [Reaction:R-RNO-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Rattus norvegicus [Reaction:R-MMU-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-156496] p-S216-CDC25C [nucleoplasm]
precedingEvent	[Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens [BlackBoxEvent:R-HSA-6798268] TP53 and E2F4 inhibit CDC25C expression - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75010
summation	[Summation:75013] A recombinant human CHEK1 forms a complex with and phosphory...
updateTrackers	[UpdateTracker:9953704] Update Tracker - [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - v93:[modifyText, removeLiteratureReference] [UpdateTracker:9791700] Update Tracker - [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - v27:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9953704] Update Tracker - [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - v93:[modifyText, removeLiteratureReference] [UpdateTracker:9791700] Update Tracker - [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - v27:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-176187] Activation of ATR in response to replication stress
(precedingEvent)	[BlackBoxEvent:R-HSA-9029987] p-S216-CDC25C translocates to the cytosol

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