Reactome | NNMT transfers CH3 from AdoMet to PY

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NNMT transfers CH3 from AdoMet to PY Show undefined attributes

catalystActivity	[CatalystActivity:10461536] pyridine N-methyltransferase activity of NNMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10461538
displayName	NNMT transfers CH3 from AdoMet to PY
eventOf	[Pathway:R-SSC-156581] Methylation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Sus scrofa
inferredFrom	[Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-175973] PY [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NNMT transfers CH3 from AdoMet to PY Pyridine can be N-methylated
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-175979] MP+ [cytosol]
precedingEvent	[Reaction:R-SSC-174391] MAT1A multimers transfer Ado from ATP to L-Met - Sus scrofa [Reaction:R-SSC-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-175987
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-156581] Methylation
(precedingEvent)	[Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy
(inferredTo)	[Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY

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