NNMT transfers CH3 from AdoMet to PY

Stable Identifier
R-HSA-175987
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Pyridine can be N-methylated
ReviewStatus
5/5
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NNMT transfers CH3 from AdoMet to PY
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Pyridine is a typical substrate for Nicotinamide N-methyltransferase (Van Haren et al. 2016).
Literature References
PubMed ID Title Journal Year
27570878 A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase

van Haren, MJ, Sastre Toraño, J, Sartini, D, Emanuelli, M, Parsons, RB, Martin, NI

Biochemistry 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

pyridine N-methyltransferase activity of NNMT [cytosol]

Physical Entity
NNMT [cytosol] (Homo sapiens)
Activity
pyridine N-methyltransferase activity (GO:0030760)
Orthologous Events
NNMT transfers CH3 from AdoMet to PY (Bos taurus)
NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)
NNMT transfers CH3 from AdoMet to PY (Canis familiaris)
NNMT transfers CH3 from AdoMet to PY (Danio rerio)
NNMT transfers CH3 from AdoMet to PY (Mus musculus)
NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)
NNMT transfers CH3 from AdoMet to PY (Sus scrofa)
NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)
Cross References
RHEA
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-27)
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