Reactome | Role of phospholipids in phagocytosis

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Role of phospholipids in phagocytosis Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
dbId	2029485
displayName	Role of phospholipids in phagocytosis
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
eventOf	[Pathway:R-HSA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2029273] PI3K binds to p-6Y-SYK - Homo sapiens [Reaction:R-HSA-2029271] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2029270] Recruitment of PLCgamma to membrane - Homo sapiens [Reaction:R-HSA-2029268] Phosphorylation and activation of PLCG - Homo sapiens [Reaction:R-HSA-2029272] Release of PLCG from FCGR - Homo sapiens [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens [Reaction:R-HSA-169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - Homo sapiens [Reaction:R-HSA-198314] DAG stimulates protein kinase C-delta - Homo sapiens [Reaction:R-HSA-2029471] Hydrolysis of PC to PA by PLD - Homo sapiens [Reaction:R-HSA-2029468] Conversion of PA into DAG by PAP-1 - Homo sapiens [BlackBoxEvent:R-HSA-2029475] Production of AA by iPLA2 upon FCGR activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
literatureReference	[LiteratureReference:2028878] Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis [LiteratureReference:2028978] The role of calcium signaling in phagocytosis [Book:2028997] Rosales, C 9780387254197 Phospholipases and Phagocytosis Molecular Mechanisms of Phagocytosis
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Role of phospholipids in phagocytosis
orthologousEvent	[Pathway:R-MMU-2029485] Role of phospholipids in phagocytosis - Mus musculus [Pathway:R-SCE-2029485] Role of phospholipids in phagocytosis - Saccharomyces cerevisiae [Pathway:R-SPO-2029485] Role of phospholipids in phagocytosis - Schizosaccharomyces pombe [Pathway:R-DDI-2029485] Role of phospholipids in phagocytosis - Dictyostelium discoideum [Pathway:R-CEL-2029485] Role of phospholipids in phagocytosis - Caenorhabditis elegans [Pathway:R-DME-2029485] Role of phospholipids in phagocytosis - Drosophila melanogaster [Pathway:R-GGA-2029485] Role of phospholipids in phagocytosis - Gallus gallus [Pathway:R-XTR-2029485] Role of phospholipids in phagocytosis - Xenopus tropicalis [Pathway:R-DRE-2029485] Role of phospholipids in phagocytosis - Danio rerio [Pathway:R-SSC-2029485] Role of phospholipids in phagocytosis - Sus scrofa [Pathway:R-BTA-2029485] Role of phospholipids in phagocytosis - Bos taurus [Pathway:R-CFA-2029485] Role of phospholipids in phagocytosis - Canis familiaris [Pathway:R-RNO-2029485] Role of phospholipids in phagocytosis - Rattus norvegicus
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2029485
summation	[Summation:2028795] Phospholipases play an integral role in phagocytosis by gene...
updateTrackers	[UpdateTracker:9785400] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v52:[updateContainedRLE] [UpdateTracker:9783663] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v56:[updateContainedRLE] [UpdateTracker:9781290] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v61:[updateContainedRLE] [UpdateTracker:9864006] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v88:[updateContainedRLE]

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(updatedInstance)

[UpdateTracker:9785400] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v52:[updateContainedRLE]
[UpdateTracker:9783663] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v56:[updateContainedRLE]
[UpdateTracker:9781290] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v61:[updateContainedRLE]
[UpdateTracker:9864006] Update Tracker - [Pathway:2029485] Role of phospholipids in phagocytosis - v88:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis

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