Reactome | Exocytosis of Insulin

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Exocytosis of Insulin Show undefined attributes

authored	[InstanceEdit:349842] May, B, 2008-05-13 13:18:27
catalystActivity	[CatalystActivity:387385] SNARE binding activity of Core SNARE Complex [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:216813] secretory granule membrane
created	[InstanceEdit:265162] May, B, 2008-04-15 08:41:29
dbId	265166
deleted	[Deleted:660805] Deletion of instance: 400073
displayName	Exocytosis of Insulin
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
eventOf	[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
figure	[Figure:266136] /figures/InsulinExocytosis1.jpg [Figure:266137] /figures/InsulinExocytosis2.jpg
goBiologicalProcess	[GO_BiologicalProcess:19568] insulin secretion
inferredFrom	[BlackBoxEvent:R-MMU-216883] Exocytosis of Insulin - Mus musculus
input	[Complex:R-HSA-386977] 6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] [EntityWithAccessionedSequence:R-HSA-265011] C Peptide [secretory granule lumen] 3 × [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [EntityWithAccessionedSequence:R-HSA-2029017] SNAP25 [plasma membrane] [Complex:R-HSA-265191] STX1A:STXBP1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-265193] SYT5 [secretory granule membrane] [EntityWithAccessionedSequence:R-HSA-376363] VAMP2 [secretory granule membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:445603] Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients [LiteratureReference:445607] Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus [LiteratureReference:264310] Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells [LiteratureReference:264300] Insulin secretion: a high-affinity Ca2+ sensor after all? [LiteratureReference:264260] Insulin vesicle release: walk, kiss, pause ... then run [LiteratureReference:264297] Molecular determinants of regulated exocytosis [LiteratureReference:264263] Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion [LiteratureReference:264262] Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion [LiteratureReference:400089] Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits [LiteratureReference:400064] Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2 [LiteratureReference:400054] Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400059] Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice [LiteratureReference:400072] Mechanisms of inhibition of insulin release [LiteratureReference:446521] Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase
maxDepth	1
modified	[InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30
name	Exocytosis of Insulin
output	4 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [EntityWithAccessionedSequence:R-HSA-265157] INS(57-87) [extracellular region] 6 × [Complex:R-HSA-74674] Insulin [extracellular region] [Complex:R-HSA-265202] SNARE Complex [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2980862] STXBP1 [plasma membrane] 2 × [SimpleEntity:R-ALL-158417] Zn2+ [extracellular region]
precedingEvent	[Reaction:R-HSA-265645] Calcium Influx through Voltage-gated Calcium Channels - Homo sapiens [BlackBoxEvent:R-HSA-381644] ER calcium channels open in response to activated PKA - Homo sapiens [Reaction:R-HSA-169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-422251] Negative regulation by 'G-alpha(i,o):GTP [plasma membrane]' [NegativeRegulation:R-HSA-741369] Negative regulation by 'Voltage-gated Calcium Channels Type Cav1 (closed) [plasma membrane]' [NegativeRegulation:R-HSA-741372] Negative regulation by 'Potassium Channel, open (pancreatic beta cell) [plasma membrane]'
regulationReference	[RegulationReference:9642641] Negative regulation by 'Voltage-gated Calcium Channels Type Cav1 (closed) [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [RegulationReference:9642657] Negative regulation by 'G-alpha(i,o):GTP [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [RegulationReference:9643006] Negative regulation by 'Potassium Channel, open (pancreatic beta cell) [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-265166
summation	[Summation:265194] Exocytosis of insulin-zinc granules occurs by the calcium-de...
updateTrackers	[UpdateTracker:9791599] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v28:[modifyText] [UpdateTracker:9775035] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v80:[add_removeInput] [UpdateTracker:9786560] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v49:[add_removeOutput, modifyText, removeRegulator] [UpdateTracker:9791543] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v29:[addRegulator] [UpdateTracker:9787945] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v44:[add_removeInput, add_removeOutput] [UpdateTracker:9864194] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v88:[modifyText, removeSummation] [UpdateTracker:9791307] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v31:[add_removeLiteratureReference] [UpdateTracker:9790358] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v33:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9776083] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v78:[addSummation] [UpdateTracker:9791475] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v30:[addRegulator]

Referrals

(inferredTo)	[BlackBoxEvent:R-MMU-216883] Exocytosis of Insulin
(hasEvent)	[Pathway:R-HSA-422356] Regulation of insulin secretion
(replacementInstances)	[Deleted:660805] Deletion of instance: 400073
(updatedInstance)	[UpdateTracker:9791599] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v28:[modifyText] [UpdateTracker:9775035] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v80:[add_removeInput] [UpdateTracker:9786560] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v49:[add_removeOutput, modifyText, removeRegulator] [UpdateTracker:9791543] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v29:[addRegulator] [UpdateTracker:9787945] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v44:[add_removeInput, add_removeOutput] [UpdateTracker:9864194] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v88:[modifyText, removeSummation] [UpdateTracker:9791307] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v31:[add_removeLiteratureReference] [UpdateTracker:9790358] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v33:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9776083] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v78:[addSummation] [UpdateTracker:9791475] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v30:[addRegulator]

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