Reactome | VEGFR2 mediated cell proliferation

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VEGFR2 mediated cell proliferation Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5218919] Garapati, P V, 2013-12-20
crossReference	[DatabaseIdentifier:12819579] BioModels Database:BIOMD0000000464 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	5218921
displayName	VEGFR2 mediated cell proliferation
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-4420153] p-6Y-VEGFR2 binds PLCG1 - Homo sapiens [Reaction:R-HSA-4420121] SFKs phosphorylate PLCG1 - Homo sapiens [Reaction:R-HSA-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Homo sapiens [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens [Reaction:R-HSA-169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens [Reaction:R-HSA-5218821] PDK1 phosphorylates PKC - Homo sapiens [Reaction:R-HSA-5218805] PKC autophosphorylates - Homo sapiens [Reaction:R-HSA-5218813] DAG and Ca+2 bind to PKC and tether it to membrane - Homo sapiens [Reaction:R-HSA-5218823] PKC phosphorylates sphingosine kinase 1 - Homo sapiens [Reaction:R-HSA-5218845] p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-12-13
literatureReference	[LiteratureReference:5576988] Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies [LiteratureReference:5576982] The reception and the party after: how vascular endothelial growth factor receptor 2 explores cytoplasmic space [LiteratureReference:5577031] Signal transduction by vascular endothelial growth factor receptors
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	VEGFR2 mediated cell proliferation
orthologousEvent	[Pathway:R-SCE-5218921] VEGFR2 mediated cell proliferation - Saccharomyces cerevisiae [Pathway:R-SPO-5218921] VEGFR2 mediated cell proliferation - Schizosaccharomyces pombe [Pathway:R-DDI-5218921] VEGFR2 mediated cell proliferation - Dictyostelium discoideum [Pathway:R-CEL-5218921] VEGFR2 mediated cell proliferation - Caenorhabditis elegans [Pathway:R-DME-5218921] VEGFR2 mediated cell proliferation - Drosophila melanogaster [Pathway:R-GGA-5218921] VEGFR2 mediated cell proliferation - Gallus gallus [Pathway:R-XTR-5218921] VEGFR2 mediated cell proliferation - Xenopus tropicalis [Pathway:R-DRE-5218921] VEGFR2 mediated cell proliferation - Danio rerio [Pathway:R-SSC-5218921] VEGFR2 mediated cell proliferation - Sus scrofa [Pathway:R-BTA-5218921] VEGFR2 mediated cell proliferation - Bos taurus [Pathway:R-CFA-5218921] VEGFR2 mediated cell proliferation - Canis familiaris [Pathway:R-RNO-5218921] VEGFR2 mediated cell proliferation - Rattus norvegicus [Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5218921
summation	[Summation:5218415] VEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-d...
updateTrackers	[UpdateTracker:9778869] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v67:[updateContainedRLE] [UpdateTracker:9783448] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v56:[updateContainedPathway] [UpdateTracker:9780807] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v62:[removeHasEvent, updateContainedRLE] [UpdateTracker:9786329] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v50:[addLiteratureReference] [UpdateTracker:9784719] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v53:[add_removeHasEvent] [UpdateTracker:9785068] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v52:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9778869] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v67:[updateContainedRLE]
[UpdateTracker:9783448] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v56:[updateContainedPathway]
[UpdateTracker:9780807] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v62:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9786329] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v50:[addLiteratureReference]
[UpdateTracker:9784719] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v53:[add_removeHasEvent]
[UpdateTracker:9785068] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v52:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway

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