Reactome | Dimerization of phosphorylated IRF3/IRF7

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Dimerization of phosphorylated IRF3/IRF7 Show undefined attributes

authored	[InstanceEdit:450360] Shamovsky, V, 2009-12-16
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
dbId	168933
displayName	Dimerization of phosphorylated IRF3/IRF7
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
followingEvent	[Reaction:R-HSA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - Homo sapiens
input	2 × [DefinedSet:R-HSA-450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:434040] X-ray crystal structure of IRF-3 and its functional implications
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Dimerization of phosphorylated IRF3/IRF7
orthologousEvent	[Reaction:R-GGA-434027] Dimerization of Phospho-IRF3 - Gallus gallus [Reaction:R-GGA-168933] Dimerization of phosphorylated IRF3/IRF7 - Gallus gallus [Reaction:R-XTR-168933] Dimerization of phosphorylated IRF3/IRF7 - Xenopus tropicalis [Reaction:R-DRE-168933] Dimerization of phosphorylated IRF3/IRF7 - Danio rerio [Reaction:R-SSC-168933] Dimerization of phosphorylated IRF3/IRF7 - Sus scrofa [Reaction:R-BTA-168933] Dimerization of phosphorylated IRF3/IRF7 - Bos taurus [Reaction:R-CFA-168933] Dimerization of phosphorylated IRF3/IRF7 - Canis familiaris [Reaction:R-RNO-168933] Dimerization of phosphorylated IRF3/IRF7 - Rattus norvegicus [Reaction:R-MMU-168933] Dimerization of phosphorylated IRF3/IRF7 - Mus musculus
output	[DefinedSet:R-HSA-450256] phosphorylated IRF3 and/or IRF7 dimer [cytosol]
precedingEvent	[Reaction:R-HSA-918229] Phosphorylation and release of IRF3/IRF7 - Homo sapiens [Reaction:R-HSA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168933
summation	[Summation:433793] Phosphorylation results in IRF-3 dimerization and removal of...
updateTrackers	[UpdateTracker:9790941] Update Tracker - [Reaction:168933] Dimerization of phosphorylated IRF3/IRF7 - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9790941] Update Tracker - [Reaction:168933] Dimerization of phosphorylated IRF3/IRF7 - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
(hasEvent)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 [Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[Reaction:R-HSA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus