Reactome | Dimerization of phosphorylated IRF3/IRF7

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Dimerization of phosphorylated IRF3/IRF7 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10238513
displayName	Dimerization of phosphorylated IRF3/IRF7
eventOf	[Pathway:R-CFA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Canis familiaris [Pathway:R-CFA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - Canis familiaris
inferredFrom	[Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-CFA-166258] phospho-IRF3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dimerization of phosphorylated IRF3/IRF7
output	[Complex:R-CFA-166272] p-T,4S-IRF3:p-T,4S-IRF3 [cytosol]
precedingEvent	[Reaction:R-CFA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-168933
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9013973] TICAM1-dependent activation of IRF3/IRF7 [Pathway:R-CFA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[Reaction:R-CFA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus
(inferredTo)	[Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7

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