Reactome | Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex

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Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:937068] protein serine/threonine kinase activity of activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:166244] de Bono, B, 2005-08-23 08:43:35
dbId	166245
displayName	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
eventOf	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Homo sapiens
followingEvent	[Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7 - Homo sapiens
input	[Complex:R-HSA-937070] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] 6 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
orthologousEvent	[Reaction:R-GGA-433786] Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 - Gallus gallus [Reaction:R-GGA-433826] Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3 - Gallus gallus [Reaction:R-GGA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Gallus gallus [Reaction:R-DRE-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Danio rerio [Reaction:R-SSC-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Sus scrofa [Reaction:R-BTA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Bos taurus [Reaction:R-CFA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Canis familiaris [Reaction:R-RNO-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Rattus norvegicus [Reaction:R-MMU-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Mus musculus
output	[DefinedSet:R-HSA-936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] 6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [DefinedSet:R-HSA-450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol]
precedingEvent	[Reaction:R-HSA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166245
summation	[Summation:450284] Human IRF-3 is activated through a two step phosphorylation ...
updateTrackers	[UpdateTracker:9788198] Update Tracker - [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - v43:[modifyText] [UpdateTracker:9789354] Update Tracker - [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - v38:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9788198] Update Tracker - [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - v43:[modifyText] [UpdateTracker:9789354] Update Tracker - [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - v38:[removeRegulator]
(hasEvent)	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7

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