Reactome | Dimerization of phosphorylated IRF3/IRF7

Dimerization of phosphorylated IRF3/IRF7

Stable Identifier

R-HSA-168933

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
        
        Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)

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Dimerization of phosphorylated IRF3/IRF7

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Phosphorylation results in IRF-3 dimerization and removal of an autoinhibitory structure to allow interaction with the coactivators CBP/p300.

Literature References

PubMed ID	Title	Journal	Year
14555995	X-ray crystal structure of IRF-3 and its functional implications Takahasi, K, Suzuki, NN, Horiuchi, M, Mori, M, Suhara, W, Okabe, Y, Fukuhara, Y, Terasawa, H, Akira, S, Fujita, T, Inagaki, F	Nat Struct Biol	2003
12692549	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Fitzgerald, KA, McWhirter, SM, Faia, KL, Rowe, DC, Latz, E, Golenbock, DT, Coyle, AJ, Liao, SM, Maniatis, T	Nat Immunol	2003