Reactome | PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

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PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane Show undefined attributes

catalystActivity	[CatalystActivity:10518008] phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10518010
displayName	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
eventOf	[Pathway:R-XTR-1660516] Synthesis of PIPs at the early endosome membrane - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Xenopus tropicalis [Reaction:R-XTR-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806238] PI(3,4)P2 [early endosome membrane]
isInDisease	false
isInferred	true
name	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806200] PI3P [early endosome membrane]
precedingEvent	[Reaction:R-XTR-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1676162
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1660516] Synthesis of PIPs at the early endosome membrane
(precedingEvent)	[Reaction:R-XTR-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 [Reaction:R-XTR-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane
(inferredTo)	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane