Reactome | PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

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PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806226] phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity of INPP5(2) [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1675949
displayName	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-8870332] PTPN13:PLEKHA1,2 bind PI(3,4)P2 - Homo sapiens [Reaction:R-HSA-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-1675834] PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676071] Identification and characterization of a novel inositol polyphosphate 5-phosphatase [LiteratureReference:1676031] Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation [LiteratureReference:1675778] Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase [LiteratureReference:1676110] Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 [LiteratureReference:1675871] Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles [LiteratureReference:1676186] The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells [LiteratureReference:1676130] Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein [LiteratureReference:913454] A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells [LiteratureReference:1675774] The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
orthologousEvent	[Reaction:R-MMU-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Mus musculus [Reaction:R-PFA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Plasmodium falciparum [Reaction:R-RNO-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Canis familiaris [Reaction:R-SCE-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-BTA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Bos taurus [Reaction:R-CEL-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Gallus gallus [Reaction:R-XTR-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Danio rerio [Reaction:R-SSC-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Sus scrofa
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1675949
summation	[Summation:1675912] At the plasma membrane, phosphatidylinositol 5-phosphatases ...

Referrals

(precedingEvent)

[Reaction:R-HSA-8870332] PTPN13:PLEKHA1,2 bind PI(3,4)P2
[Reaction:R-HSA-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
[BlackBoxEvent:R-HSA-1675834] PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
[Reaction:R-HSA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
[Reaction:R-HSA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

(hasEvent)

[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane

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